Intrinsic ageing, also known as the natural ageing process, is a continuous process that normally begins in our mid-20s. Within the skin, collagen production slows, and elastin, the substance that enables skin to snap back into place, has a bit less spring. Dead skin cells do not shed as quickly and turnover of new skin cells may decrease slightly. While these changes usually begin in our 20s, the signs of intrinsic ageing are typically not visible for decades.
As one ages, the skin's elasticity declines dramatically, wrinkles become evident and gravity constantly pulls on our bodies. Changes related to gravity become more pronounced and one of the earliest signs of facial ageing is the development of jowls. These changes get worse with age, so, the sooner one begins treatment for preventing or correction, the better. The jowls are areas of skin and fat that have fallen from the side of the face to hang along or below the jawline. Previously there was no alternative to surgical face lifts .The choices were fairly black and white; surgery or sagging!
Now with the advent of skin tightening devices and skin rejuvenation procedures, virtually any patient in their thirties or above can be a candidate for a little tightening and firming and the younger the patient the better the result. Eight out of ten patients get noticeable improvement in skin laxity after the first treatment and ten out of ten will be putting collagen "in the bank" for the future.
In addition ageing is a complex phenomenon which is genetically programmed according to a biological clock. But pre-mature ageing can occur due to external environmental factors such as UV rays, pollution, smoking which produce free radicals. Human skin is a living organ which performs dynamic activities such as growth, repair, movement and maintenance. Even though our skin requires cytokines and growth factors as key modulators of skin cell metabolism, their levels decreases with the ageing process which results in slow cell renewal and defective skin defence systems. If exogenous cytokines and growth factors are put into the aged skin by Transdermal Mesotherapy, they improve skin elasticity and plasticity via accelerated rejuvenating process.