Cosmelan Depigmentation at a Glance

Best Results 1 - 2
Duration of Results 8 - 12 months
Treatment Recovery 7 - 10 days
Risks & Complications Medium
Anaesthetic None
Procedure Time 30 mins
Skin Specialist Therapist
Back To Work Next day - 4 days

Cosmelan treatment guarantees the improvement of the anti-aesthetic skin blemishes with a very high safety margin. Cosmelan Depigmentation treatment’s principal action is the elimination of melanin patches on the face - melasma. Also called chloasma if the pigmentation occurs with pregnancy Cosmelan Depigmentation treatment involves a very versatile, dynamic process that is easily adapted to the needs of each individual patient.

At Skin Renewal, to improve results with Cosmelan, a Mesoestetic Melanostop Peel is applied immediately before the mask treatment at no extra cost.

Frequently Asked Questions

The Cosmelan treatment is available in Johannesburg at FourwaysParkhurstMorningside, BedfordviewWest Rand, Waterfall and Illovo as well as in Pretoria at Brooklyn and Irene and in the Western Cape at Cape QuarterClaremontConstantiaStellenboschWillowbridgePaarl, and in KwaZulu-Natal at BallitoDurban & Umhlanga.

Skin aging caused by systematic sun exposure, facial blemishes due to excessive pigmentation, and, in general, imperfections caused by melanin, are more and more common problems today. “Dark blemishes”, especially on hands and face, are one of the greatest aesthetic concerns of modern men and women… It will only be possible to remove the anti-aesthetic skin blemishes and recover the smoothness of the skin, bringing back its luminosity, with a treatment that has a direct effect on the intimate formation process of the pigment (melanin).

Cosmelan Depigmentation treatment action mechanism is based on the inhibition of tyrosinase, a basic enzyme in the melanin formation process. Several of the substances present in the Cosmelan® formula act by blocking this enzyme, or even by inverting the metabolic process of the transformation chain. Melanogenesis comprises the following stages:

  • TYROSINE proceeds to DOPA by means of TYROSINASE.
  • DOPA proceeds to DOPAQUINONE by means of TYROSINASE.
  • DOPAQUINONE proceeds to PHAEOMELANINE and EUMELANIN by means of oxidation and cyclization.

The Cosmelan Depigmentation treatment offers a series of major advantages and benefits compared with other types of depigmentation products found in the market:

  • Very effective in all types of Melasma especially deep-seated severe Melasma or post-inflammatory hyperpigmentation PIH
  • Effective for pigmentation that has failed to resolve after traditional skin lightening topical products
  • Effective for pigmentation that has failed to resolve after traditional treatments such as superficial peels
  • Rapid and easy depigmenting action
  • Compatible with ALL skin types (Fitzpatrick I – VI)
  • Light peeling effect
  • Treatment can be used all year round
  • Beneficial for acne patients and the PIH after acne has resolved
  • Does not contain Hydroquinone or TCA
  • High safety margin

In 99% of the cases, the disappearance of the blemishes improves by 95%...
ONE WEEK after starting the Cosmelan® Depigmentation treatment, a noticeable significant improvement of the skin is observed! The reduction of the treated blemish is detected and the appearance of new luminous and rejuvenated skin is present.

At the end of the Cosmelan® Depigmentation treatment, the blemishes start to disappear altogether, so that, although the patient may be able to “locate” the place where the spot was, the truth is that the pigmentation will have disappeared and nobody will be able to see it just by looking at it

Cosmelan works by blocking the process that causes hyperpigmentation. It works for:

  • Melasma
  • Brown Spots
  • Blotchy Skin
  • Hyperpigmentation
  • Post-inflammatory hyperpigmentation of dermatitis and acne cars
  • Prevention of hyperpigmentation post-laser and post-peel

Cosmelan 1 – mask

  • Azelaic Acid, Kojic Acid, Phytic Acid, Ascorbic Acid, Arbutine, and Titanium Dioxide

Cosmelan 2 – Maintenance Cream (30g)

  • Titanium Dioxide, Kojic Acid, Phytic Acid, Ascorbic Acid

Mesoestetic Hydra Vital Factor K Cream (50ml)

  • Hydro nutritional cream for face and neck. Hydroviton, Vitamin K, Vitamin E, Amniotic fluid, Glycerine, Silicone oil.

Important: it must be known if the patient has undergone any previous treatments, especially with glycolic acid. If confirmed, any treatment, especially Glycolic Acid, must be eliminated at least, one week prior to using Cosmelan Depigmentation treatment.

The Cosmelan® Depigmentation treatment initiated at the medical office must be continued at home, on a daily basis, according to the guidelines indicated.

The treatment must not be interrupted under any circumstances, during the whole time prescribed.

It is completely forbidden to combine the Cosmelan® Depigmentation treatment with other depigmentation treatments, as the appearance of undesired effects cannot be guaranteed.

Treatment control visits are recommended. 8 days after the beginning of treatment, 15 days after, and a follow-up visit every month thereafter.

The first and second day

During the first two days of the treatment, the skin may turn red. If the skin is very sensitive, the patient may experience an itching feeling. Slight burning and tightening of the skin is also absolutely normal, especially during the first 24 to 48 hours after starting the treatment. To relieve these problems, it is advisable to apply the Mesoestetic Hydra-vital factor K whenever necessary.

Reddening of the skin. The reddening that occurs on the face after applying the Mesoestetic Cosmelan mask treatment is similar to the effects of day-long exposure to the sun in the snow without protection. (Intense reddening in phototype I and II and practically nonexistent in phototype IV and V).

Flaking may occur on all skin types (and more intensely in phototypes I and II) between the second and third day. In this case, it is advisable to apply the Mesoestetic® Hydra-vital factor K cream, repeating this every two hours on the day when the flaking is most intense repeating this every 2 hours until it improves. Do not pull on the flakes. Do not rub or scratch the skin. If necessary flakes can be cut off. Do not use exfoliants, scrubs, or peels. Avoid steam baths, saunas, and swimming in a hot spring for 2 weeks following treatment. It is advisable to wait until the initial flaking period is over before starting to apply make-up again.


If a severe skin reaction results from treatment do not proceed with maintenance treatment. Similarly, if scab formation is seen or if the skin is accidentally injured during the treatment period it is advisable to interrupt the application of maintenance treatment. Use only Hydra-vital factor K and Sunscreen until the skin has settled and then again proceed with the maintenance treatment schedule. If in doubt, please contact your doctor at Skin Renewal immediately.

Third and fourth day. After the third or fourth day, the skin appears healthy and luminous and the marks begin to fade.

HOME TREATMENT – Cosmelan Maintenance Cream

The second phase of the Cosmelan consists of a home maintenance cream Cosmelan with the intention of securing the depigmentation by the association of agents such as Kojic Acid, Phytic Acid, and Vitamin C. We have added a physical agent to block the sun and guarantee that the UV rays do not keep on aggravating unwanted cutaneous hyperpigmentation.

The period following the initial 6-month treatment process is called the STABILISATION period, and this can ideally be extended up to one year. Every effort should be made to continue treatment throughout the first summer. Even if the treatment is a great success, the long-term success depends on how well the protocol is followed, during both the treatment and stabilization phases. A VERY GOOD sunblock is essential at all times.

IMPORTANT NOTE: The treatment results are largely dependent on your cooperation and adherence to the post-treatment skincare! The first 4 months constitute the treatment period. The period following is called the stabilization period, and this is ideally extended up to one year, or longer. Every effort should be made to continue treatment throughout the first summer. Even if the depigmentation treatment was a great success, you need to understand that long-term success depends on how well the protocol is followed, during both the treatment and stabilization phases. Avoid sun exposure for 2 weeks prior to treatment.

  • No peels can be done 2 weeks prior to treatment
  • No Laser treatment can be done on the area to be treated 2 days prior to peel
  • Avoid Botox and Filler in the area to be treated 2 weeks prior to the peel

8 Reviews (average: 5 out of 5)

See all reviews
*Please note results may vary by individuals.
Review -Face Pigmentation
Reviewed on 7 July 2018 by Lulu Khumalo

Well it was my first time to come and know more about my pigmentation on my face. I was so scared that maybe they will say there is nothing that they can do

because I have been like this for a very long time. But surprisingly the staff was excellent. Starting from the reception to the Dr. Will recommend Bedfrodview to everyone.

Review -Highlight of my experience!
Reviewed on 1 December 2015 by Cherylee Symes

The therapist is a absolute sweetie pie. Lovely person with a very nice personality. The highlight of my experience.

Review -​I have been coming here for years!
Reviewed on 26 November 2015 by Chauke

I have been coming here for years now and been with Kelly throughout. I am very pleased with her work and have been seeing great results as well. She is professional as well as really relaxed, calm and makes the experience really special all the time.

Review -Extremely friendly!
Reviewed on 26 November 2015 by Yana Clara

Extremely friendly and thorough when making an appointment as well as being fully informative.

Review -Consistent Professional Excellence!
Reviewed on 26 October 2015 by Sorina Oberholzer

Melissa is highly personable and extremely professional. I trust her skill and recommendations implicitly and I am comfortable around her (she also happen to be one of my favourite people all round). She delivers consistently high treatment standards!

Review -Cosmelan is amazing!
Reviewed on 17 August 2015 by K.M from Cape Quarter

The Cosmelan treatment is the best thing that ever happened to my skin. Pigmentation is almost gone, my skin texture is amazing and my skin looks radiant. My skin therapist was amazing, she followed up with me and answered all my questions. Cosmelan is amazing!

Review -Absolutely Wonderful!
Reviewed on 23 September 2014 by Anonymous
Kelly has been absolutely wonderful with me, answering all my questions with a smile and just being really great!
Review -A huge change!
Reviewed on 25 August 2014 by Fortunate Dube
I love that all treatments that have been done on my face have made a huge change to my skin not much breakouts and discoloration anymore.
Sharon Izak Elaine Chat staff ) WhatsApp