Cryotherapy is not recommended for certain areas of the body because of the danger of destruction of tissue or unacceptable scarring. These areas include skin that overlies nerves, the corners of the eyes, the fold of skin between the nose and lip, the skin surrounding the nostrils, and the border between the lips and the rest of the face.
Lesions that are suspected or known to be malignant melanoma should not be treated with cryotherapy, but should instead be removed surgically. Similarly, basal cell or squamous cell carcinomas that have reappeared at the site of a previously treated tumor should also be removed surgically. If it remains unclear whether a growth is benign or malignant, a sample of tissue should be removed for analysis (biopsy) by a pathologist before any attempts to destroy the lesion with cryotherapy.
Care should be taken in people with diabetes or certain circulation problems when cryotherapy is considered for growths located on their lower legs, ankles, and feet. In these patients, healing can be poor and the risk of infection can be higher than for other patients.