Biostimulation Overview

Biostimulation and bio-remodelling treatments are available in Gauteng at the Morningside, Parkhurst, Rosebank, Bedfordview, Fourways, Waterfall, West Rand, Irene, Lynnwood and Brooklyn clinics, as well as in the Western Cape at Big Bay, Cape Quarter, Claremont, Constantia, Century City, Stellenbosch, Paarl and Willowbridge clinics, and KwaZulu-Natal at the Ballito, Durban and Umhlanga clinics.

Biostimulation is a non-surgical rejuvenation technique that utilises injectable biostimulators to stimulate your skin’s natural regeneration processes. While traditional mesotherapy focuses on hydrating and nourishing the skin’s surface, biostimulation goes deeper, awakening fibroblast activity to boost collagen, elastin, and hyaluronic acid production. Over time, this results in firmer, smoother, and more radiant skin that looks naturally refreshed rather than “filled.”

Depending on your specific skin concerns, the biostimulatory solution may contain compounds such as Calcium Hydroxyapatite (CaHA), poly-L-lactic acid (PLLA), or Polycaprolactone (PCL) - all of which are scientifically proven to stimulate collagen production. These may be combined with hyaluronic acid, vitamins, peptides, and amino acids to enhance hydration and support cellular metabolism. Your Skin Renewal doctor will select the most suitable formulation for your skin type and treatment goals.

Injectable mesotherapy with biostimulators can be performed on the face, neck, décolletage, and hands, areas most prone to early signs of ageing and loss of elasticity. It is especially effective for improving fine lines, crepiness, dullness, and overall skin quality. Some protocols may also be applied to the upper arms or knees, where skin laxity is mild to moderate.

Results are progressive rather than instant. Most patients notice an improvement in skin tone and hydration within a few days, while visible collagen and elastin renewal becomes apparent after 4–6 weeks.

During the treatment, a fine needle or cannula is used to deliver micro-injections into targeted areas. The procedure is generally well-tolerated and can be performed with topical anaesthesia for added comfort. After treatment, mild redness or pinpoint swelling may appear but usually resolves within 24–48 hours. There is no significant downtime; most patients return to normal activities immediately.

Yes. When performed by an experienced medical professional using approved products, biostimulatory injections are considered safe and well-tolerated. The substances used (CaHA, PLLA, and PCL) are biocompatible and biodegradable, meaning the body naturally absorbs them over time. Minor side effects, such as temporary redness, bruising, or swelling, are generally short-lived.

Results develop gradually and can last 12–24 months, depending on the specific product used, your age, skin condition, and lifestyle factors such as sun exposure and smoking. Because biostimulation works by stimulating your own collagen, the improvements are long-lasting and natural-looking, not dependent on the product remaining under the skin.

Absolutely. Biostimulation works effectively as part of a combination protocol, enhancing the results of other rejuvenating treatments, such as microneedling, laser skin resurfacing, radiofrequency tightening, carboxytherapy, or chemical peels. It can also complement bioremodeling or skin booster treatments to address different layers of the skin simultaneously, a holistic approach that delivers the “multiplier effect” for which Skin Renewal is known.

Ideal candidates are individuals experiencing early to moderate signs of ageing, mild skin laxity, or a dull complexion who wish to improve skin quality without surgery or excessive volume enhancement. It’s also a perfect choice for younger patients seeking preventative rejuvenation and for those who prefer gradual, natural-looking results.

Biostimulation is not recommended for pregnant or breastfeeding women, or for individuals with active skin infections, severe inflammation, or autoimmune conditions that affect wound healing. A complete medical consultation with a Skin Renewal doctor will determine whether you’re an appropriate candidate and ensure your treatment plan is entirely safe and personalised.